General Comparative Endocrinology, 20:221235. Thiourea had a former use in the treatment of excessive thyroid gland activity. Relative to the number of persons exposed to thiourea, the number of reported contact and photocontact allergies to thiourea is small (MAK, 1997). It is a covalent compound. A similar study with male lambs showed adverse effects on male reproductive development. The English translation of this BUA report was published in 1998. Journal of General Microbiology, 64:139150. Results of the simultaneous feeding of four tumorigens to rats. Serum T4 levels were decreased by approximately 60% at week 1 and remained significantly lower than in rats treated with DHPN only throughout the experiment, while serum TSH levels were elevated and peaked at 4 weeks (20-fold increase), returning to normal at 12 weeks. Fig. Consensus report for thiourea. Friesel et al. Archivio "De Vecchi" per lAnatomia Patologica e la Medicina Clinica, 31:419. There were four control lambs. Weast R, Astle M, eds. Hashimoto A (1979) Salting-out chromatography applied to separation and analysis of mixtures of thioureas and thioacetamide by high performance liquid chromatography. The data on the water solubility of thiourea of the Ullmann handbook is chosen for robust study summary because of the reference temperature of 20 °C instead of 25 °C. IARC Scientific Publications, 147:1225. IDK if this is the case for thiourea … 143148. Degradation of thiourea by soil microorganisms was observed by Lashen & Starkey (1970). Based on a hydroxyl radical concentration of 1 × 1016 mol/litre in water, a half-life of 17 days can be calculated. Journal of Soil Contamination, 1(4):339360. Tokyo, Department of Environmental Health, Office of Health Studies, pp. For the BUA review process, the company that is in charge of writing the report (usually the largest manufacturer in Germany) prepares a draft report using literature from an extensive literature search as well as internal company studies. In limited studies in rodents, no teratogenic effects have been observed. This draft is subject to a peer review in several readings of a working group consisting of representatives from government agencies, the scientific community, and industry. Thiourea is oxidized by thyroid gland peroxidase in the presence of iodine or iodide and hydrogen peroxide to form formamidine disulfide (NH2(NH)CSSC(NH)NH2). Toxicology Letters, 38:123133. MacKenzie CG, MacKenzie JB (1943) Effect of sulfonamides and thioureas on the thyroid gland and basal metabolism. Thiourea condense with, - dicarbonyl and forms pyrimidine derivatives. The first perturbations of the blood count were observed after 56 months of exposure, and the highest incidence of the symptoms was evident in those workers who had been in contact with the chemical for 515 years (Zaslawska, 1964; Speranski et al., 1969). Thiourea had neither a maternally toxic nor a teratogenic effect when administered to rats on the 12th or 13th day of gestation as a single oral dose of 480 mg/kg body weight (Ruddick et al., 1976). Sin embargo, se puede producir alguna transformación metabólica catalizada por la monooxigenasa microsomal con flavina para formar ácido formamidínsulfínico. Formamidine disulfide is unstable and decomposes at pH values above 3.0, forming cyanamide, elementary sulfur, and thiourea. Products such as wet suits, swimming goggles, orthopaedic devices, protective gloves, and shoes containing these compounds have been shown to produce allergic contact dermatitis (Kanerva et al., 1994; McCleskey & Swerlick, 2001). Elle peut toutefois subir une certaine métabolisation en acide formamidine-sulfinique, catalysée par la monooxygénase microsomique contenant de la flavine. Here you need to note that urea and thiourea are structurally similar but very different in physical and chemical properties. Se analiza principalmente mediante cromatografía líquida de alto rendimiento con detección ultravioleta posterior. Treatment in vitro with 75 mmol thiourea/litre results in an inhibition of interleukin-8 production in human whole blood, the toxic effect of which can be suppressed by the administration of glutathione or cysteine (DeForge et al., 1992). Mutation Research, 46:305310. According to four different literature sources thiourea is soluble (1000-10000 mg/l) to very soluble (> 10000mg/l) in water: - 137.0 g/l at 20 °C (according to Ullmann, 1995) No es previsible la evaporación de tiourea a partir del agua. Freitag D, Lay J, Korte F (1984) Environmental hazard profile test results as related to structures and translation into the environment. No se ha cuantificado la exposición de la población general a la tiourea, de manera que no es posible realizar una caracterización del riesgo. Rheinheimer G, Gericke H, Wesnigk J (1990) Prüfung der biologischen Abbaubarkeit von organischen Chemikalien im umweltrelevanten Konzentrationsbereich. Its huge production clearly states its importance in the market. Central Institute for Nutrition and Food Research, Netherlands, for SKW Trostberg AG, Trostberg, 7 pp. The lumina were devoid of colloid. C=S bond distance in thiourea is 1.71, It is highly soluble in water. This tolerance was accompanied by a reduction in both lung vessel permeability and plasma histamine levels (Giri et al., 1991b). A daily dose of <15 mg (<0.2 mg/kg body weight per day for a 70-kg adult) in adults did not lead to measurable depression of the thyroid gland function, while a dose of 70 mg/day (about 1.0 mg/kg body weight per day) produced a remission of hyperthyroidism (Winkler et al., 1947). La thiourée est un antioxydant. Nature (London), 337:285288. Journal of Veterinary Medicine, Series B, 47(9):641652. Mertschenk B, Beck F, Bauer W (1995) Thiourea and thiourea derivates. Thiourea has been identified as one of the metabolites in workers exposed to carbon disulfide (Pergal et al., 1972). Arbete och hälsa, 26:97109. The accuracy of the occupational exposure data (Talakin et al., 1985) is uncertain. Indian Journal of Animal Science, 57:383387. Two studies on the effect of thiourea on L5178Y mouse lymphoma cells in tests in both the presence and the absence of a metabolic activation system (S9-mix from Aroclor 1254-induced rat liver) have been carried out. The dermal LD50 for New Zealand White rabbits is above 2800 mg/kg body weight. Measured data are not available. Agricultural and Biological Chemistry, 44:30173018. The effect of thiourea on the permeable yeast mutant S. cerevisiae C658-k42 at concentrations of 0, 0.5, 1.0, and 2.0 mg/ml was tested in both the absence and presence of metabolic activation. A single intraperitoneal dose of 125 mg thiourea/kg body weight administered to mice led to a weak increase in mutation rate (up to a factor of 3.6) in Salmonella strains TA 1530 and TA 1538 in a host-mediated assay, but negative results were obtained in Saccharomyces cerevisiae following a single intraperitoneal dose of 1000 mg/kg body weight.