The extract showed significant antipyretic effect on yeast-induced fever in rats at 600 mg/kg that persisted up to 3 h of the study. Furosemide (10 mg/kg, p.o.) Again, the overall rate of the reaction is determined by the slow step, which is the breaking of the C-OH-ZnCl 420 (fixed dose method). Diabetes, the most prevailing metabolic disorder is attracting present research attention towards it towards discovery of plant drugs. Once you have identified your unknown as a 1°, 2°, or 3° alcohol, then you will also take its infra-red Write down in was used as reference standard. The present study therefore justifies its use in the folklore remedies as an anthelmintic drug of natural origin. Single administration (single dose) of the methanol extract (200 and 400 mg/kg, p.o.) UNIT-III: E1 and E2 reactions Dr. Sumanta Mondal _ Lecture Notes _Pharmaceutical Organic Chemistry-II (BP 202T)_B.Pharm-II Sem Characteristics of E 1 reaction Characteristics of E 2 reaction. primary alcohol first to an aldehyde and then to a carboxylic acid and it will oxidize a secondary alcohol to a Finally, you will take an Infrared Spectrum of your unknown. The methanol extract of S. pinnata barks significantly reduced the numbers of writhings induced by intraperitoneal injection of acetic acid in mice at all tested dose levels in a dose dependant manner, where as the mean latency of nociceptive responses to thermal stimuli in the tail immersion test of the methanol extract of S. pinnata barks also exhibited significant response at all tested dose levels in a dose dependant manner that is comparable with response of the standard drug pentazocine (30mg/kg, p.o.). Maximum reduction was seen at doses of 200 and 400 mg/kg (34.08% and 48.94% decrease respectively) after 6 h of extract administration. The chloroform extract and methanol extract of S. pinnata significantly increased the urinary out put as well as urinary electrolyte concentration at a dose of 300 mg/kg, p.o. Record your results in your notebook. The study revealed that the root extract caused significant reduction in the blood glucose level in both normoglycaemic and alloxan induced diabetic rats at the tested dose levels in a dose dependant manner. Again, tertiary alcohols cannot be oxidized by this reagent because there is no hydrogen to be lost from the Potency of the test samples was found to be inversely proportional to the time taken for paralysis/death of the worms. alcohol to a carbonyl in the second step. Herein, a new method for directly coupling of benzyl/allyl alcohols with malonates via palladium catalyzed Tsuji-Trost type reaction was developed. tests on the three known alcohols can be done at the same time. The anthelmintic activity of various extracts of the roots of C. rutidosperma was studied against Indian earthworms Pheritima posthuma using piperazine citrate (15 mg/ml) as reference standard. was used as the reference drug. Simultaneously, the methanol and aqueous extracts were found to be the less potent and petroleum ether extract was found to be least active. secondary methyl alcohol functionality in the molecule. and piperazine citrate (15 mg/ml) were used as reference standards respectively in different models for activity comparison. A brisk effervescence due … Formation of a precipitate is a positive test. The air dried and powdered plants materials were separately extracted successively with various solvents viz. and pentazocine (30 mg/kg, p.o.) exhibited significant hypoglycaemic effect but glibenclamide and methanol extract significantly depressed the peak of blood glucose level at 90 min after glucose loading.