All benzophenone derivatives presented lower binding energies than indomethacin when their interaction with COX-2 was evaluated. Three simple and rapid spectrophotometric methods were developed for detection and trace determination of benzophenone (the main impurity) in phenytoin … (III): Intravenous self-administration of some CNS-affecting drugs and a new sleep-inducer, 1H-1, 2, 4-triazolyl benzophenone derivative (450191-S), in rats]. The present invention relates to a process for the preparation of benzophenone derivatives and comprises a selective crystallization of alkali salts of compounds of formula (I) ##STR1## wherein R 1 is lower-alkyl and R 2 is hydrogen, lower-alkyl or halogen,. Benzophenone TDI The EFSA Journal (2009) 1104, 5-30 BACKGROUND AS PROVIDED BY THE COMMISSION A recent notification from the German authorities under Art 50 of the Regulation (EC) No178/2002 on the Rapid Alert System for Food and Feed (RASFF) has reported the migration of 4-methylbenzophenone from packaging into certain cereal products in a quantity US3349133A - Derivatives of substituted benzophenone - Google Patents Derivatives of substituted benzophenone Download PDF Info Publication ... benzophenone propynyloxy reaction grams halide Prior art date 1963-12-26 Legal status (The legal status is an assumption and is not a legal conclusion. The present invention relates to a process for the preparation of benzophenone derivatives and comprises a selective crystallization of alkali salts of compounds of formula (I) ##STR1## wherein R 1 is lower-alkyl and R 2 is hydrogen, lower-alkyl or halogen, from the isomeric alkali salts of the 3-hydroxy compounds of formula (II), ##STR2## wherein R 1 and R 2 are as defined above. PubMed:Effect of food on absorption of 450191-S, a 1H-1,2,4-triazolyl benzophenone derivative from rat small intestine. from the isomeric alkali salts of the 3-hydroxy compounds of formula (II), ##STR2## wherein R 1 and R 2 are as defined above. PubMed:[Pharmacological studies on drug dependence. The first method, zero-crossing first derivative spectrophotometry, depends on measuring the first derivative trough values at 257.6 nm for benzophenone. Three simple and rapid spectrophotometric methods were developed for detection and trace determination of benzophenone (the main impurity) in phenytoin bulk powder and pharmaceutical formulations.